Home » Health » Medicine

Lipid Lowering Drugs For Treatment Of Cardiovascular Diseases

Dec 23, 2007
Lipids are biological molecules that are soluble in organic solvents and insoluble in aqueous solution. Lipids include triglycerides and cholesterol. Cholesterol is divided into two groups: Low density protein (LDL) or bad cholesterol which causes hardening of arteries and high density lipoprotein (HDL) or good cholesterol which clears cholesterol from the arteries.

The term dyslipidemia is used to describe disruption of lipid level in the blood. Most people in western countries suffer from hyperlipidemia which means elevated level of lipids in the blood caused due to faulty diet and lifestyle. Lipid and lipoprotein abnormalities are very common in general population and are regarded as high risk factor for cardiovascular diseases due to influence of cholesterol which is most prominent constituent of lipids, which in turn causes atherosclerosis. High level of bad cholesterol (LDL) is one of the major cause for various cardiovascular diseases.

Drugs that lower lipid levels are prescribed to patients suffering from high lipid levels. These drugs are known as lipid lowering drugs. These drugs are also called as anti-lipid drugs.

Broadly these anti lipid drugs are classified into five categories: Statins, fibrates, anion exchange resins, fish oils and nicotinic acid. These drugs are prescribed for patients who are suffering from coronary artery disease, heart diseases and have not responded to dietary changes and also lifestyle change

If a person has very high levels of lipids, initial therapy with one of the above category may not be sufficient; in that case combination of categories may be used as lipid lowering drugs; however combination of statin with fibrates or nicotinic acid may have increased side effects.

Statin is the class of drugs prescribed to treat high cholesterol (hyper cholestermia). Stain drugs include atoravastatin (lipitor), simvastatin (Zocor), Rosuvastatin (crestor), pravastatin (lipostat). Statin class of drugs is very effective in treating high cholesterol but less effective than fibrates. Fibrates are more effective in lowering LDL and increasing HDL, but they have their own associated side effects. In general they are effective in lowering heart strokes, atherosclerosis and other cardiovascular diseases.

The metabolism of statin in liver is similar to that of protease inhibitors using P450 CYP3A4 pathway. These protease inhibitors are dangerous and cause muscle damage and hence lot of side effects with drug interactions.

In contrast to other members of the drug class, rosuvastatin is not metabolised by the P450 pathway, hence less potential for drug interactions.

Ofcourse as they say prevention is the best cure. Proper diet and lifestyle prevents most of the cardiovascular diseases.
About the Author
The author is medical writer and writes topics on various health related issues.
For more information visit us at
www.crestor.info - cholesterol lowering drugs to know more
Rating:
Please Rate:
(Average: Not rated)
Views: 123
Print Email Report Share
Article Categories
    • Artists
    • Gambling
    • Humanities
    • Humor
    • Movies
    • Music
    • Photography
    • Tattoos
    • Television
    • Classic Cars
    • Motorcycles
    • Recreational Vehicles
    • SUVs
    • Trucks
    • Vans
    • Branding
    • Business Opportunities
    • Careers and Jobs
    • Corporate
    • Customer Service
    • Direct Mail
    • Entrepreneurship
    • Ethics
    • Financing
    • Franchising
    • Home-Based Business
    • Human Resources
    • Import and Export
    • Leadership
    • Management
    • Market Research
    • Marketing and Advertising
    • Negotiation
    • Network Marketing
    • Networking
    • Organizational
    • Presentation
    • Project Management
    • Public Relations
    • Small Business
    • Strategic Planning
    • Team Building
    • Telemarketing
    • Training
    • Data Recovery
    • Databases
    • Games
    • Hardware
    • Networks
    • Operating Systems
    • Programming
    • Security
    • Software
    • Spyware and Viruses
    • Ask an Expert
    • College and University
    • Home Schooling
    • K-12
    • Languages
    • Online Education
    • Psychology
    • Accounting
    • Credit
    • Currency Trading
    • Debt Consolidation
    • Insurance
    • Investing
    • Leasing
    • Loans
    • Mortgage
    • Mutual Funds
    • Personal Finance
    • Stock Market
    • Structured Settlements
    • Taxes
    • Wealth Building
    • Coffee
    • Cooking
    • Gourmet
    • Recipes
    • Wine and Spirits
    • Arts and Crafts
    • Babies
    • Collecting
    • Elderly Care
    • Genealogy
    • Hobbies
    • Parenting
    • Pets
    • Pregnancy
    • Woodworking
    • Feng Shui
    • Gardening
    • Home Appliances
    • Home Security
    • Interior Design
    • Landscaping
    • Affiliate Programs
    • Article Marketing
    • Auctions
    • Audio
    • Banner Advertising
    • Blogging
    • Broadband
    • Domain Names
    • E-Books
    • E-Commerce
    • Email Marketing
    • Ezines and Newsletters
    • Forums
    • Internet Marketing
    • Link Popularity
    • Pay-Per-Click
    • Podcasting
    • RSS
    • Search Engine Marketing
    • Search Engine Optimization
    • Security
    • Social Media
    • Spam
    • Video
    • Viral Marketing
    • Web Design
    • Web Development
    • Web Hosting
    • Copyright
    • Cyber Law
    • Intellectual Property
    • National, State, Local
    • Patents
    • Regulatory Compliance
    • Trademarks
    • Buying
    • Selling
    • Baseball
    • Basketball
    • Boating
    • Cycling
    • Extreme Sports
    • Fishing
    • Football
    • Golf
    • Hockey
    • Hunting
    • Martial Arts
    • Running
    • Scuba Diving
    • Soccer
    • Swimming
    • Tennis
    • Dating
    • Divorce
    • Marriage
    • Weddings
    • Astrology
    • Buddhism
    • Christianity
    • Faith
    • Hinduism
    • Islam
    • Judaism
    • Meditation
    • Metaphysical
    • New Age
    • Cable and Satellite TV
    • Cell Phones
    • Communication
    • Gadgets and Gizmos
    • GPS
    • Satellite Radio
    • Video Conferencing
    • VoIP
    • Addictions
    • Coaching
    • Goal Setting
    • Motivational
    • Stress Management
    • Time Management
    • Clothing
    • Electronics
    • Fashion
    • Gifts
    • Jewelry
    • Causes and Organizations
    • Environment
    • History
    • Holidays
    • Men's Issues
    • Nature
    • Philosophy
    • Politics
    • Women's Issues
    • World Affairs
    • Air Travel
    • Camping
    • Cruises
    • Destinations
    • Outdoors
    • Article Writing
    • Book Reviews
    • Copywriting
    • Fiction
    • Non-Fiction
    • Poetry
    • Quotes
    • Screenplay
    • Tools and Resources